HRID1027095

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)O)cnc12

HCID67540739

未命名化合物

HCID67541402

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3cc(C)ccc3C)c(C(=O)N3CCC4(CC3)COc3cc(F)ccc34)cnc12

HCID67540872

未命名化合物

收率 76%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 7-(2,5-dimethylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.123 g, 0.347 mmol) obtained in Example 88, step 2 and 6-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.079 g, 0.382 mmol), the title compound (0.142 g, 76%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3774f8069d54cf5bcdf63aa6e2cf70e
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24]([OH:26])=O.Cl.[F:28][C:29]1[CH:34]=[CH:33][C:32]2[C:35]3([CH2:41][O:42][C:31]=2[CH:30]=1)[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]3>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:24]([N:38]1[CH2:39][CH2:40][C:35]2([C:32]3[CH:33]=[CH:34][C:29]([F:28])=[CH:30][C:31]=3[O:42][CH2:41]2)[CH2:36][CH2:37]1)=[O:26]