4-Fluoro-2-methylaniline → HCID 67540871, compound

HRID 1027097Notes

Reaction equation

HRID 1027097 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[F:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[C:23]([CH3:28])[CH:22]=1>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:25][C:24]3[CH:26]=[CH:27][C:21]([F:20])=[CH:22][C:23]=3[CH3:28])=[C:3]([C:16]([O:18][CH3:19])=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 679824-Fluoro-2-methylanilineHCID 86646292HCID 86646292, compound

Product 1

HCID 67540871HCID 67540871, compoundYield 100.4%

Procedure

In the same manner as in Example 1, step 4 and using methyl 7-chloro-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (2.80 g, 9.87 mmol) obtained in Example 21, step 2 and 4-fluoro-2-methylaniline (1.85 g, 14.8 mmol), the title compound (3.69 g, 100%) was obtained.

Sources & evidence

ORD record
ord-dc4b4fde7fd64d0a9416c70802177e79
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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