HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid → 3-Ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)-6-(6-fluoro-2h-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid | HCID 67540076 | — |
| Reactant | 6-Fluoro-2H-spiro[1-benzofuran-3,4'-piperidine] hydrochloride | HCID 67541402 | — |
| Product | 3-Ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)-6-(6-fluoro-2h-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine | HCID 67539971 | 75.5% |
Reaction Steps
In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.130 g, 0.363 mmol) obtained in step 2 and 6-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.082 g, 0.399 mmol), the title compound (0.150 g, 75%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729264B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f76678928c70450abb2061a6d9961a36 |
| Source note | uspto-grants-2014_05 |