3-Fluoro-4-methylaniline → HCID 67540360, compound

HRID 1027099Notes

Reaction equation

HRID 1027099 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:6]2[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH3:19])=[O:17].[F:20][C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=1[CH3:28])[NH2:24]>>[CH2:14]([O:13][C:11]([C:10]1[CH:9]=[N:8][N:7]2[C:2]([NH:24][C:23]3[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([F:20])[CH:22]=3)=[C:3]([C:16]([O:18][CH3:19])=[O:17])[CH:4]=[N:5][C:6]=12)=[O:12])[CH3:15]

Participants

3

Reactant 2

HCID 99573-Fluoro-4-methylanilineHCID 86646292HCID 86646292, compound

Product 1

HCID 67540360HCID 67540360, compoundYield 94%

Procedure

In the same manner as in Example 1, step 4 and using methyl 7-chloro-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylate (3.00 g, 10.6 mmol) obtained in Example 21, step 2 and 3-fluoro-4-methylaniline (1.43 ml, 12.7 mmol), the title compound (3.67 g, 94%) was obtained.

Sources & evidence

ORD record
ord-5d86ccb5df0e462baa01d17ab1cd3ede
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

Loading…