HRID1027100

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)c1cnn2c(Nc3ccc(C)c(F)c3)c(C(=O)O)cnc12

HCID67540365

未命名化合物

HCID67541402

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cnn2c(Nc3ccc(C)c(F)c3)c(C(=O)N3CCC4(CC3)COc3cc(F)ccc34)cnc12

HCID67540549

未命名化合物

收率 96.1%

PROCEDURE

实验过程

In the same manner as in Example 21, step 5 and using 3-ethoxycarbonyl-7-(3-fluoro-4-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.130 g, 0.363 mmol) obtained in step 2 and 6-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.082 g, 0.399 mmol), the title compound (0.191 g, 96%) was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2f717f0f6c1a47d6a12f105bf2fa8223
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([F:23])[CH:17]=3)=[C:13]([C:24](O)=[O:25])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[F:28][C:29]1[CH:34]=[CH:33][C:32]2[C:35]3([CH2:41][O:42][C:31]=2[CH:30]=1)[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]3>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([F:23])[CH:17]=3)=[C:13]([C:24]([N:38]3[CH2:37][CH2:36][C:35]4([C:32]5[CH:33]=[CH:34][C:29]([F:28])=[CH:30][C:31]=5[O:42][CH2:41]4)[CH2:40][CH2:39]3)=[O:25])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]