7-(2-Chloro-5-methylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid → 7-(2-Chloro-5-methylphenylamino)-3-ethoxycarbonyl-6-(6-fluoro-2h-spiro[benzofuran-3,4'-piperidine]-1'-ylcarbonyl)pyrazolo[1,5-a]pyrimidine

Participants

Reaction Steps

In the same manner as in Example 21, step 5 and using 7-(2-chloro-5-methylphenylamino)-3-ethoxycarbonylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.130 g, 0.347 mmol) obtained in Example 66, step 2 and 6-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.079 g, 0.382 mmol), the title compound (0.195 g, 100%) was obtained.

Provenance & Evidence