HCID 67540408, compound → HCID 178469965, compound

HRID 1027107Notes

Reaction equation

HRID 1027107 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[F:20][C:21]1[C:26]2[O:27][CH2:28][C:29]3([CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[C:25]=2[CH:24]=[CH:23][CH:22]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:32]3[CH2:33][CH2:34][C:29]4([C:25]5[CH:24]=[CH:23][CH:22]=[C:21]([F:20])[C:26]=5[O:27][CH2:28]4)[CH2:30][CH2:31]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 67540408HCID 67540408, compoundHCID 178469973HCID 178469973, compound

Product 1

HCID 178469965HCID 178469965, compoundYield 79%

Procedure

In the same manner as in Example 19, step 3 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.416 g, 1.66 mmol) obtained in Example 19, step 2 and 7-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.500 g, 1.99 mmol) obtained in Reference Example 5, the title compound (0.570 g, 79%) was obtained.

Workup

  1. customobtained in Reference Example 5

Sources & evidence

ORD record
ord-fbcfd16bc2154d56966faa3849d82201
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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