Cyclopropanesulfonamide → HCID 67541270, compound

HRID 1027111Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19](O)=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][C:27]2([C:33]3[CH:34]=[CH:35][CH:36]=[C:37]([F:38])[C:32]=3[O:31][CH2:30]2)[CH2:26][CH2:25]1)=[O:23].[CH:39]1([S:42]([NH2:45])(=[O:44])=[O:43])[CH2:41][CH2:40]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]2[N:16]=[CH:17][C:18]([C:19]([NH:45][S:42]([CH:39]3[CH2:41][CH2:40]3)(=[O:44])=[O:43])=[O:20])=[C:14]2[N:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][C:27]2([C:33]3[CH:34]=[CH:35][CH:36]=[C:37]([F:38])[C:32]=3[O:31][CH2:30]2)[CH2:26][CH2:25]1)=[O:23]

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67540569HCID 67540569, compound

Product 1

HCID 67541270HCID 67541270, compoundYield 84.8%

Procedure

In the same manner as in Example 1, step 6 and using 7-(2-fluoro-5-methylphenylamino)-6-(7-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.130 g, 0.251 mmol) obtained in step 2 and cyclopropanesulfonamide (0.155 g, 0.125 mmol), the title compound (0.066 g, 42%) was obtained.

Sources & evidence

ORD record: ord-30ec9cb8c32941c4ac418222cb5db0ab
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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