Cyclopropanesulfonamide → HCID 67540545, compound

HRID 1027115Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:32]4[CH:33]=[CH:34][CH:35]=[C:36]([F:37])[C:31]=4[O:30][CH2:29]3)[CH2:25][CH2:24]2)=[O:22])=[C:4]([CH3:38])[CH:3]=1.[CH:39]1([S:42]([NH2:45])(=[O:44])=[O:43])[CH2:41][CH2:40]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:45][S:42]([CH:39]4[CH2:41][CH2:40]4)(=[O:44])=[O:43])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:24][CH2:25][C:26]3([C:32]4[CH:33]=[CH:34][CH:35]=[C:36]([F:37])[C:31]=4[O:30][CH2:29]3)[CH2:27][CH2:28]2)=[O:22])=[C:4]([CH3:38])[CH:3]=1

Participants

Reactant 2

HCID 15765418Cyclopropanesulfonamide

HCID 67541054HCID 67541054, compound

Product 1

HCID 67540545HCID 67540545, compoundYield 64%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-fluoro-2-methylphenylamino)-6-(7-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.079 g, 0.152 mmol) obtained in step 2 and cyclopropanesulfonamide (0.092 g, 0.760 mmol), the title compound (0.051 g, 64%) was obtained.

Sources & evidence

ORD record: ord-0bce0ae0beed41f48689ac6844e7d9b7
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

Loading…