Ethanesulfonamide → HCID 67541437, compound

HRID 1027118Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:32]4[C:33]([F:37])=[CH:34][CH:35]=[CH:36][C:31]=4[O:30][CH2:29]3)[CH2:25][CH2:24]2)=[O:22])=[C:4]([CH3:38])[CH:3]=1.[CH2:39]([S:41]([NH2:44])(=[O:43])=[O:42])[CH3:40]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:44][S:41]([CH2:39][CH3:40])(=[O:43])=[O:42])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:24][CH2:25][C:26]3([C:32]4[C:33]([F:37])=[CH:34][CH:35]=[CH:36][C:31]=4[O:30][CH2:29]3)[CH2:27][CH2:28]2)=[O:22])=[C:4]([CH3:38])[CH:3]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67541268HCID 67541268, compound

Product 1

HCID 67541437HCID 67541437, compoundYield 27.3%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-fluoro-2-methylphenylamino)-6-(4-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.025 g, 0.048 mmol) obtained in step 4 and ethanesulfonamide (0.026 g, 0.241 mmol), the title compound (0.008 g, 27%) was obtained.

Sources & evidence

ORD record: ord-d55dcbc17763426abe6f825bf9f89fde
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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