HCID 19366964, compound → HCID 178469964, compound

HRID 1027119Notes

Reaction equation

HRID 1027119 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([OH:18])=O)[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2].Cl.[F:20][C:21]1[CH:22]=[CH:23][C:24]2[O:34][CH2:33][C:27]3([CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[C:25]=2[CH:26]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([OH:15])=[C:13]([C:16]([N:30]3[CH2:31][CH2:32][C:27]4([C:25]5[CH:26]=[C:21]([F:20])[CH:22]=[CH:23][C:24]=5[O:34][CH2:33]4)[CH2:28][CH2:29]3)=[O:18])[CH:12]=[N:11][C:10]=12)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 19366964HCID 19366964, compoundHCID 178469973HCID 178469973, compound

Product 1

HCID 178469964HCID 178469964, compoundYield 64.3%

Procedure

In the same manner as in Example 1, step 2 and using 3-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylic acid (0.416 g, 1.66 mmol) obtained in Example 19, step 2 and 5-fluoro-2H-spiro[benzofuran-3,4′-piperidine]hydrochloride (0.500 g, 1.99 mmol) obtained in Reference Example 3, the title compound (0.470 g, 54%) was obtained.

Workup

  1. customobtained in Reference Example 3

Sources & evidence

ORD record
ord-45e54bb3356640cb8d10abd9bc8d683a
Source dataset
uspto-grants-2014_05
Patent number
US08729264B2

Reaction notes

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