Ethanesulfonamide → HCID 67539456, compound

HRID 1027121Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:37][CH2:36][C:8]3([CH2:13][CH2:12][N:11]([C:14]([C:16]4[CH:17]=[N:18][C:19]5[N:20]([N:30]=[CH:31][C:32]=5[C:33](O)=[O:34])[C:21]=4[NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])=[O:15])[CH2:10][CH2:9]3)[C:6]=2[CH:7]=1.[CH2:38]([S:40]([NH2:43])(=[O:42])=[O:41])[CH3:39]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:37][CH2:36][C:8]3([CH2:9][CH2:10][N:11]([C:14]([C:16]4[CH:17]=[N:18][C:19]5[N:20]([N:30]=[CH:31][C:32]=5[C:33]([NH:43][S:40]([CH2:38][CH3:39])(=[O:42])=[O:41])=[O:34])[C:21]=4[NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])=[O:15])[CH2:12][CH2:13]3)[C:6]=2[CH:7]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67539733HCID 67539733, compound

Product 1

HCID 67539456HCID 67539456, compoundYield 84%

Procedure

In the same manner as in Example 1, step 6 and using 6-(5-fluoro-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)-7-(2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.122 g, 0.243 mmol) obtained in step 4 and ethanesulfonamide (0.133 g, 1.23 mmol), the title compound (0.121 g, 84%) was obtained.

Sources & evidence

ORD record: ord-f11a1e9e93034c1a891db5308526fa56
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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