反应详情

N-[7-Benzylamino-6-(1-(tert-butoxycarbonyl)spiro[indoline-3,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulfonamide (0.062 g, 0.094 mmol) obtained in step 3 was dissolved in 4 mol/L hydrogen chloride-dioxane solution, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the obtained crystals and the mixture was suction-filtered to give the title compound (0.036 g, 42%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate
2. additionwas added to the obtained crystals
3. filtrationthe mixture was suction-filtered