Ethanesulfonamide → HCID 67540752, compound

HRID 1027131Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[C:30]([CH3:38])([CH3:37])[O:29]3)[CH2:25][CH2:24]2)=[O:22])=[C:4]([CH3:39])[CH:3]=1.[CH2:40]([S:42]([NH2:45])(=[O:44])=[O:43])[CH3:41]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:45][S:42]([CH2:40][CH3:41])(=[O:44])=[O:43])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][C:26]3([C:36]4[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:30]([CH3:38])([CH3:37])[O:29]3)[CH2:25][CH2:24]2)=[O:22])=[C:4]([CH3:39])[CH:3]=1

Participants

Reactant 2

HCID 73702Ethanesulfonamide

HCID 67540463HCID 67540463, compound

Product 1

HCID 67540752HCID 67540752, compoundYield 58.8%

Procedure

In the same manner as in Example 1, step 6 and using 7-(4-fluoro-2-methylphenylamino)-6-(3,3-dimethyl-3H-spiro[isobenzofuran-1,4′-piperidine]-1′-ylcarbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.12 g, 0.23 mmol) obtained in step 2 and ethanesulfonamide (0.12 g, 1.17 mmol), the title compound (0.084 g, 58%) was obtained.

Sources & evidence

ORD record: ord-d1069ee44b7649c2bc27c29621eb297c
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

Loading…