Ammonium Acetate → HCID 178525168, compound

Participants

Reaction Conditions

Reaction Steps

(S)-3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-1,8-dioxa-4-aza-spiro[4.5]decane-4-carboxylic acid benzyl ester (1.13 gm, 2.18 mmol) was dissolved in xylenes (11 mL), ammonium acetate (0.84 gm, 10.94 mmol) was added as a solid and the mixture was heated at 140° C. for 24 h. The mixture was diluted with ethyl acetate (50 mL) and the organic layer was washed (aqueous NaHCO3, water, brine) and dried. This crude product was purified by silica gel chromatography (3:2 mixture of EtOAc:hexanes) to afford 0.62 gm (57%) of the title compound. LCMS 500.9 (M+2)

Provenance & Evidence