Trifluoroacetic acid → HCID 178525169, compound

Participants

Reaction Steps

(R)-3-(4-{4′-[2-((S)-1-tert-Butoxycarbonyl-pyrrolidin-2-yl)-1H-imidazol-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-1,8-dioxa-4-aza-spiro[4.5]decane-4-carboxylic acid benzyl ester (0.04 gm, 0.05 mmol) was dissolved in DCM (2 mL), TFA (2 mL) was added and the mixture stirred for 2 hours. The solvent was evaporated, the residue redissolved in EtOAc (20 mL) and the organics washed with aqueous NaHCO3, water and brine. Drying the organic layer afforded (R)-3-{4-[4′-((S)-2-pyrrolidin-2-yl-1H-imidazol-4-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-1,8-dioxa-4-aza-spiro[4.5]decane-4-carboxylic acid benzyl ester (0.015 gm, 44%). LCMS 631.0 (M+1).

Provenance & Evidence