Hydrochloric Acid → HCID 67387160, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 2-(5-(4′-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-4-ethyl-2H-pyrrole-1(5H)-carboxylate (intermediate 26) (0.171 g, 0.248 mmol) in dioxane (4 mL) was added a solution of 5.5N HCl in dioxane (2.5 mL) at 0° C. The mixture was stirred at room temperature for 20 hours. The resulting mixture was concentrated to give 2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-5-(4′-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazole (Intermediate 29) (0.121 g, yield: 83%) as a brown solid. ES LC-MS m/z=451 (M+H)+.

Provenance & Evidence