3-Methoxynaphthalene-2-boronic acid → HCID 86710602, compound

HRID 1027205Notes

Reaction equation

HRID 1027205 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:22][O:23][C:24]1[C:25](B(O)O)=[CH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][CH:30]=[CH:29][CH:28]=2>>[CH3:22][O:23][C:24]1[C:25]([C:2]2[N:7]=[N:6][C:5]([CH2:8][CH:9]3[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]3)=[CH:4][CH:3]=2)=[CH:26][C:27]2[C:32]([CH:33]=1)=[CH:31][CH:30]=[CH:29][CH:28]=2

Participants

3

Reactant 2

HCID 108889523-Methoxynaphthalene-2-boronic acidHCID 86710601HCID 86710601, compound

Product 1

HCID 86710602HCID 86710602, compoundYield 45%

Procedure

tert-butyl 4-((6-(3-methoxynaphthalen-2-yl)pyridazin-3-yl)methyl)piperidine-1-carboxylate (63 mg, 0.145 mmol, 45% yield) was prepared from tert-butyl 4-((6-chloropyridazin-3-yl)methyl)piperidine-1-carboxylate and (3-methoxynaphthalen-2-yl)boronic acid using GENERAL METHODS 1-4.

Sources & evidence

ORD record
ord-be672d9cee814de4ac5839b8b5f48191
Source dataset
uspto-grants-2014_05
Patent number
US08729263B2

Reaction notes

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