HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine → HCID 86710617, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine | HCID 86710539 | — |
| Reactant | 4-Benzyloxy-2-(trifluoromethoxy)phenylboronic acid | HCID 86710618 | — |
| Product | HCID 86710617 | HCID 86710617 | — |
Reaction Steps
(4-(Benzyloxy)-2-(trifluoromethoxy)phenyl)boronic acid (1.2 g, 61% pure, 2.307 mmol) and Intermediate 1-1 (246 mg, 0.871 mmol) were reacted according to GENERAL METHOD 1-5 for Suzuki coupling. Compound 6-(4-(benzyloxy)-2-(trifluoromethoxy)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine was obtained as a beige solid (405 mg, 90% yield) after flash column chromatography purification. MS (M+1)=515.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729263B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-303c09b43f1a43daab0eabe231f94ce1 |
| Source note | uspto-grants-2014_05 |