HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,6-Dimethoxyphenyl)boronic acid → HCID 86710637, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,6-Dimethoxyphenyl)boronic acid | HCID 2734343 | — |
| Reactant | 6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine | HCID 86710539 | — |
| Product | HCID 86710637 | HCID 86710637 | — |
Reaction Steps
Intermediate 1-1 (566 mg, 2.0 mmol) and 2,6-dimethoxyphenylboronic acid (437 mg, 2.4 mmol) were reacted according to GENERAL METHOD 1-5 for Suzuki coupling. 6-(2,6-Dimethoxyphenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine was obtained as a beige solid (375 mg, 49% yield) after flash column chromatography purification. MS (M+1)=385.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729263B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-5ff63d499ac745b89cf9fb0a9e5c6b6e |
| Source note | uspto-grants-2014_05 |