Acetyl chloride → Methoxybenzyl chloride

HRID 1027339Notes

Reaction equation

HRID 1027339 reaction equation
[CH3:1][O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C([Cl:15])(=O)C>>[CH3:1][O:2][CH:3]([Cl:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 62375Benzaldehyde dimethyl acetal

Product 1

HCID 11062637Methoxybenzyl chlorideYield 96.8%

Conditions

Temperature
45 °C

Procedure

To a 300 mL-volume Kjeldahl flask, 50 g of benzaldehyde dimethyl acetal and 27.08 g of acetyl chloride were added, and the mixture was stirred at 45° C. for 3 hours. After the reaction, the low boiling point residue was removed under reduced pressure to obtain 49.8 g of α-chlorobenzyl methyl ether.

Workup

  1. customAfter the reaction
  2. customthe low boiling point residue was removed under reduced pressure

Sources & evidence

ORD record
ord-0f5a44527e924176ad0e3f24e0f5a1c2
Source dataset
uspto-grants-2014_05
Patent number
US08735048B2

Reaction notes

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