HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-(2-oxoethyl)cyclohexanecarboxylate → 2-{4-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-2-aza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-(2-oxoethyl)cyclohexanecarboxylate | HCID 23021124 | — |
| Reactant | 4-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine | HCID 67479147 | — |
| Product | 2-{4-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenyl}-2-aza-spiro[4.5]decan-1-one | HCID 67479056 | — |
Reaction Steps
The title compound was synthesized in the manner essentially the same as the Example 1 by condensing 1-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester (Intermediate 6) with 4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 14), and subsequently cyclization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735385B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-06d49413ef0644cca6fb4f92c1975e92 |
| Source note | uspto-grants-2014_05 |