HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 54591694, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 67479068 | HCID 67479068 | — |
| Reactant | HCID 86677563 | HCID 86677563 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54591694 | HCID 54591694 | — |
Reaction Steps
The title compound was synthesized in the manner essentially the same as the Example 1 by condensing 4-(tert-butyl-diphenyl-silanyloxy)-1-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester (Intermediate 8) with 4-[(S)-3-(2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 15), and subsequently cyclization, followed by de-protection with TBAF in THF at 60° C. for 5 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735385B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ff09b104ab664351bea0a3c873282373 |
| Source note | uspto-grants-2014_05 |