HCID 67479068, compound → HCID 54591765, compound

HRID 1027419Notes

Reaction equation

HRID 1027419 reaction equation
CO[C:3]([C:5]1([CH2:15][CH:16]=O)[CH2:10][CH2:9][CH:8]([C:11]([O:13][CH3:14])=[O:12])[CH2:7][CH2:6]1)=[O:4].[CH3:18][CH:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH:24]1[CH2:28][CH2:27][C@H:26]([C:29]2[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=2)[CH2:25]1>>[CH3:14][O:13][C:11]([CH:8]1[CH2:7][CH2:6][C:5]2([C:3](=[O:4])[N:35]([C:32]3[CH:33]=[CH:34][C:29]([CH:26]4[CH2:27][CH2:28][CH:24]([N:20]5[CH2:21][CH2:22][CH2:23][CH:19]5[CH3:18])[CH2:25]4)=[CH:30][CH:31]=3)[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:12]

Participants

3

Reactant 2

HCID 67479068HCID 67479068, compound2×HCID 86677561HCID 86677561, compound2×

Product 1

HCID 54591765HCID 54591765, compound

Procedure

The title compound was synthesized in the manner essentially the same as the Example 1 by condensing 1-(2-oxo-ethyl)-cyclohexane-1,4-dicarboxylic acid dimethyl ester (Intermediate 5) with 4-[(S)-3-(2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 15), and subsequently cyclization.

Sources & evidence

ORD record
ord-df84562336dc414aaf9c820801e1f5b0
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

Loading…