HCID 58478452, compound → HCID 54591766, compound

HRID 1027420Notes

Reaction equation

HRID 1027420 reaction equation
C(O[C:4]([C:6]1([CH2:19][CH2:20]C=O)[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5])C.[CH3:23][CH:24]1[CH2:28][CH2:27][CH2:26][N:25]1[CH:29]1[CH2:33][CH2:32][C@H:31]([C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[CH:36][CH:35]=2)[CH2:30]1>>[C:15]([O:14][C:12]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:40]([C:37]3[CH:38]=[CH:39][C:34]([CH:31]4[CH2:32][CH2:33][CH:29]([N:25]5[CH2:26][CH2:27][CH2:28][CH:24]5[CH3:23])[CH2:30]4)=[CH:35][CH:36]=3)[CH2:20][CH2:19]2)[CH2:11][CH2:10]1)=[O:13])([CH3:16])([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 58478452HCID 58478452, compound2×HCID 67479068HCID 67479068, compound2×

Product 1

HCID 54591766HCID 54591766, compound

Procedure

The title compound was synthesized in the manner essentially the same as the Example 1 by condensing 4-(3-oxo-propyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (Intermediate 4) with 4-[(S)-3-(2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 15), and subsequently cyclization.

Sources & evidence

ORD record
ord-98c0f30ec01e46448f39c9ad785a1cb4
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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