HCID 67479068, compound → HCID 54591767, compound

HRID 1027421Notes

Reaction equation

HRID 1027421 reaction equation
CO[C:3]([C:5]1([CH2:10][CH2:11][CH:12]=O)[CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:14][CH:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH:20]1[CH2:24][CH2:23][C@H:22]([C:25]2[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=2)[CH2:21]1>>[CH3:14][CH:15]1[CH2:19][CH2:18][CH2:17][N:16]1[CH:20]1[CH2:24][CH2:23][CH:22]([C:25]2[CH:30]=[CH:29][C:28]([N:31]3[CH2:12][CH2:11][CH2:10][C:5]4([CH2:9][CH2:8][CH2:7][CH2:6]4)[C:3]3=[O:4])=[CH:27][CH:26]=2)[CH2:21]1

Participants

3

Reactant 2

HCID 67479068HCID 67479068, compound2×HCID 86677562HCID 86677562, compound2×

Product 1

HCID 54591767HCID 54591767, compound

Procedure

The title compound was synthesized in the manner essentially the same as the Example 1 by condensing 1-(3-oxo-propyl)-cyclopentanecarboxylic acid methyl ester (Intermediate 7) with 4-[(S)-3-(2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenylamine (Intermediate 15), and subsequently cyclization.

Sources & evidence

ORD record
ord-e40ee88a7caf4074906ad4574c5f2202
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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