(R)-2-Methylpyrrolidine → 2-{4-[4-((R)-2-Methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one

Participants

Reaction Steps

The title compound was synthesized in the manner essentially the same as the Example 9 by condensing cis-methanesulfonic acid 4-[4-(1-oxo-8-oxa-2-aza-spiro[4.5]dec-2-yl)-phenyl]-cyclohexyl ester (Intermediate 21) (30 mg, 0.07 mmol, 1 equiv.) and (R)-2-methylpyrrolidine.

Provenance & Evidence