HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-methylpyrrolidine → 2-{4-[4-((S)-2-Methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-methylpyrrolidine | HCID 6999702 | — |
| Reactant | HCID 178505315 | HCID 178505315 | — |
| Product | 2-{4-[4-((S)-2-Methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-8-oxa-2-aza-spiro[4.5]decan-1-one | HCID 54591841 | — |
Reaction Steps
The title compound was synthesized in the manner essentially the same as the Example 9 by condensing cis-methanesulfonic acid 4-[4-(1-oxo-8-oxa-2-aza-spiro[4.5]dec-2-yl)-phenyl]-cyclohexyl ester (Intermediate 21) (30 mg, 0.07 mmol, 1 equiv.) and (S)-2-methylpyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735385B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-56d2b970144f4e20babe35f99c241831 |
| Source note | uspto-grants-2014_05 |