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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1027432Generated: November 1, 2026

Hydrochloric Acid → 2-{2-Fluoro-4-[4-((R)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

https://huagongshe.com/reaction/1027432

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-{2-Fluoro-4-[4-((R)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl esterHCID 54591843—
Solvent1,4-DioxaneHCID 31275—
Product2-{2-Fluoro-4-[4-((R)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-2,8-diaza-spiro[4.5]decan-1-one hydrochlorideHCID 54591921—

Reaction Steps

The title compound was prepared in the same manner as Example 17 by using hydrochloric acid in dioxane to hydrolyze 2-{2-fluoro-4-[4-((R)-2-methyl-pyrrolidin-1-yl)-cyclohexyl]-phenyl}-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08735385B2
Source datasetuspto-grants-2014_05
ORD IDord-76625baea57d41e694c007106b27b25f
Source noteuspto-grants-2014_05