2-(Trifluoromethoxy)benzoyl Chloride → HCID 67478860, compound

HRID 1027444Notes

Reaction equation

HRID 1027444 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:8]1.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](Cl)=[O:25]>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=3[O:21][C:20]([F:19])([F:31])[F:32])=[CH:14][CH:13]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 27772412-(Trifluoromethoxy)benzoyl ChlorideHCID 674791474-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine2×

Product 1

HCID 67478860HCID 67478860, compound

Procedure

The title compound was synthesized essentially in the same manner as Example 28 by employing 4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 14) and 2-trifluoromethoxybenzoyl chloride.

Sources & evidence

ORD record
ord-95c531751de54144bb6cec68bdafe3d8
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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