4-(Trifluoromethoxy)benzoyl Chloride → HCID 67479036, compound

HRID 1027445Notes

Reaction equation

HRID 1027445 reaction equation
[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:8]1.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[CH3:1][C@H:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:11][CH2:10][C@H:9]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:26](=[O:27])[C:25]3[CH:29]=[CH:30][C:22]([O:21][C:20]([F:19])([F:31])[F:32])=[CH:23][CH:24]=3)=[CH:14][CH:13]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 1421104-(Trifluoromethoxy)benzoyl ChlorideHCID 674791474-[(S)-3-((S)-2-Methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine2×

Product 1

HCID 67479036HCID 67479036, compound

Procedure

The title compound was synthesized essentially in the same manner as Example 28 by employing 4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine (Intermediate 14) and 4-trifluoromethoxybenzoyl chloride.

Sources & evidence

ORD record
ord-034bdf91e4f44bbe9fcc42e353b81c0d
Source dataset
uspto-grants-2014_05
Patent number
US08735385B2

Reaction notes

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