HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → HCID 58382530, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 58382527 | HCID 58382527 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58382530 | HCID 58382530 | 9.1% |
Reaction Steps
A mixture of 37 mg of benzoic acid, 110 mg of [(benzotriazol-1-yloxy)-dimethylamino-methylene]-dimethyl-ammonium tetrafluoroborate (TBTU), 100 mg of 1-amino-3-{4-[5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-propan-2-ol (example 20) and 104 mg of ethyldiisopropylamine in 2 ml of dimethylformamide was stirred for 16 h at room temperature. After removal of the solvent the product was isolated via preparative HPLC (method HPLC2) to yield 11 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735387B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-e8718d453be74c14accf9d6b27e4e2f9 |
| Source note | uspto-grants-2014_05 |