Morpholine → HCID 58382519, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 230 mg of 2-[4-(3-bromo-propoxy)-3,5-dimethyl-phenyl]-5-(4-chloro-benzyl)-7-propoxy-oxazolo[5,4-d]pyrimidine, 74 mg of morpholine and 233 mg of potassium carbonate in 5 ml of dimethylformamide was heated to 60° C. for 3 h. After cooling to room temperature, the solids were removed by filtration. The solvent was distilled off in vacuo and the residue was purified by preparative HPLC to yield 137 mg of the title compound in the form of the 5-(4-chloro-benzyl)-2-[3,5-dimethyl-4-(3-morpholin-4-yl-propoxy)-phenyl]-7-propoxy-oxazolo[5,4-d]pyrimidine trifluoroacetic acid salt.

Provenance & Evidence