HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Nonyne → 3-(1-phenylsulfonyl-4-non-1-ynyl-1H-pyrazol-3-yl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Nonyne | HCID 18937 | — |
| Reactant | 3-(1-phenylsulfonyl-4-iodo-1H-pyrazol-3-yl)-pyridine | HCID 57548066 | — |
| Reactant | 3-(4-Hex-1-ynyl-1H-pyrazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine | HCID 178442470 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-(1-phenylsulfonyl-4-non-1-ynyl-1H-pyrazol-3-yl)-pyridine | HCID 67283963 | 80% |
| Product | 3-(4-Non-1-ynyl-1H-pyrazol-3-yl)-pyridine | HCID 178442740 | — |
Reaction Steps
Compound 44C was prepared following the procedure as described for the synthesis of compound 44A (see Scheme 9) using non-1-yne and 3-(1-phenylsulfonyl-4-iodo-1H-pyrazol-3-yl)-pyridine (36B). (flash chromatography with diethyl ether/PE 1/1) to afford 3-(1-phenylsulfonyl-4-non-1-ynyl-1H-pyrazol-3-yl)-pyridine (43C) as an oil (80%). (TLC diethyl ether Rf 0.44).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735388B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-5b2d6d9ba38b4dc3a65c3d29f8b57d73 |
| Source note | uspto-grants-2014_05 |