3-Phenylpropane-1-thiol → HCID 178420287, compound

HRID 1027550Notes

Reaction equation

HRID 1027550 reaction equation
[CH2:1]([S:6][C:7]1[C:8]([CH:12]2[CH:17]3[CH2:18][CH2:19][N:14]([CH2:15][CH2:16]3)[CH2:13]2)=[N:9][NH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[C:20]1(CCCS)[CH:25]=CC=C[CH:21]=1>>[CH2:1]([S:6][C:7]1[C:8]([CH:12]2[CH:17]3[CH2:18][CH2:19][N:14]([CH2:15][CH2:16]3)[CH2:13]2)=[N:9][NH:10][CH:11]=1)[CH2:2][C:3]1[CH:25]=[CH:20][CH:21]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 905963-Phenylpropane-1-thiolHCID 178447695HCID 178447695, compound

Product 1

HCID 178420287HCID 178420287, compoundYield 11%

Procedure

Compound 49G was prepared following the procedure as described for the synthesis of compound 49B (see Scheme 10) using 3-phenyl-1-propanethiol as reagent. Subsequent purification by flash chromatography (EtOH) afforded compound 49G.

Workup

  1. customSubsequent purification by flash chromatography (EtOH)

Sources & evidence

ORD record
ord-b31e8cc5547245ddbecf77c9b69f178d
Source dataset
uspto-grants-2014_05
Patent number
US08735388B2

Reaction notes

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