反应详情

To a vigorously stirred solution of pyridinium chlorochromate and celite in dichloromethane (20 mL) at room temperature was added a solution of 2-(2-bromopyridin-3-yl)-1-(3-chlorophenyl)ethanol in dichloromethane (10 mL). The mixture was stirred at room temperature for 3 hours then filtered through a plug of silica gel, eluted well with dichloromethane and concentrated in vacuo. Purification by chromatography on silica gel gave 2-(2-bromopyridin-3-yl)-1-(3-chlorophenyl)ethanone (313 mg, 64% yield) as white solid.

1. filtrationthen filtered through a plug of silica gel
2. washeluted well with dichloromethane
3. concentrationconcentrated in vacuo
4. customPurification by chromatography on silica gel