1-Methyl-3-aminopyrazole → N,N-dimethyl-5-(2-methyl-6-((1-methyl-1H-pyrazol-3-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide

HRID 1027710Notes

Reaction equation

HRID 1027710 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH2:7])=[N:3]1.[CH3:8][N:9]([CH3:34])[C:10]([C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[C:24]3[CH:25]=[C:26]([CH3:28])[O:27][C:23]=3[CH:22]=[C:21]([C:29](OCC)=[O:30])[CH:20]=2)=[CH:14][N:13]=1)=[O:11]>>[CH3:34][N:9]([CH3:8])[C:10]([C:12]1[N:17]=[CH:16][C:15]([O:18][C:19]2[C:24]3[CH:25]=[C:26]([CH3:28])[O:27][C:23]=3[CH:22]=[C:21]([C:29](=[O:30])[NH:7][C:4]3[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=3)[CH:20]=2)=[CH:14][N:13]=1)=[O:11]

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 59483316Ethyl 4-(2-(dimethylcarbamoyl)pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylate

Product 1

HCID 46916695N,N-dimethyl-5-(2-methyl-6-((1-methyl-1H-pyrazol-3-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide

Procedure

The title compound (4) was prepared by a method analogous to that described in Example 1 using 1-methyl-1H-pyrazol-3-amine and ethyl 4-(2-(dimethylcarbamoyl)pyrimidin-5-yloxy)-2-methylbenzofuran-6-carboxylate (I-2a)

Sources & evidence

ORD record
ord-23ba6e513b0b4b86b300dc888c902fc3
Source dataset
uspto-grants-2014_05
Patent number
US08735396B2

Reaction notes

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