HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aspirin → 2-Acetoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aspirin | HCID 2244 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Acetoxybenzoyl chloride | HCID 79668 | — |
Reaction Steps
To a solution of compound 2-acetoxybenzoic acid (1.0 g, 5.5 mmol) in THF (30 mL) was added (COCl)2 (0.8 ml, 9.1 mmol) at 0° C. The mixture was heated (reflux, 1.5 h) and concentrated under reduced pressure to afford 2-(chlorocarbonyl)phenyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08735378B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-1c668c593c4e4112b70e6b8a5c396e5d |
| Source note | uspto-grants-2014_05 |