HCID 68006850, compound → HCID 51034090, compound

HRID 1027794Notes

Reaction equation

HRID 1027794 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[N:6][C:7](/[CH:11]=[CH:12]/[C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)=[N:8][CH:9]=2)[N:4]([C:23]([N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:24])[C:3]1=[O:30]>CO.[Pd]>[CH3:1][N:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:22])[F:21])=[CH:15][CH:14]=3)=[N:8][CH:9]=2)[N:4]([C:23]([N:25]2[CH2:26][CH2:27][CH2:28][CH2:29]2)=[O:24])[C:3]1=[O:30]

Participants

4

Reactant 1

HCID 68006850HCID 68006850, compound

Product 1

HCID 51034090HCID 51034090, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 7-methyl-9-(pyrrolidin-1-ylcarbonyl)-2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-7,9-dihydro-8H-purine-8-one <the compound of Example 243> (50 mg) in methanol (10 ml) was added 10% palladium on carbon (5 mg) and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. After removing the catalyst from the reaction mixture, the solvent was evaporated under reduced pressure, and the residue was dried to give the title compound 38 mg.

Workup

  1. customAfter removing the catalyst from the reaction mixture
  2. customthe solvent was evaporated under reduced pressure
  3. customthe residue was dried

Sources & evidence

ORD record
ord-866e1dca3b8a4483a7e964d7d8e86032
Source dataset
uspto-grants-2014_05
Patent number
US08735406B2

Reaction notes

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