Hydrochloric Acid → HCID 69225494, compound

Participants

Reaction Conditions

Reaction Steps

Dimethyl carbonate (20 mL) was treated with NaH (60% dispersed in oil, 660 mg, 46 mmol), heated at 85° C., treated dropwise with a solution of 7,8,9,10-tetrahydro-6H-benzocycloocten-5-one (prepared according to Richard W. Thies, J. Org. Chem. 42(2), 280-281, 1977) (950 mg, 5.5 mmol) in dimethyl carbonate (10 mL), stirred at 85-90° C. for three hours, cooled to 0° C., acidified by the slow addition of 1 M HCl (50 mL) and extracted with ether (150 mL). The organic was isolated, washed with brine, dried (MgSO4) and concentrated to provide the title compound.

Provenance & Evidence