Trifluoroacetic acid → HCID 25071628, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 30A (38 mg, 0.096 mmol) in CH2Cl2 (1 mL) was treated with TFA (2 mL), heated at 60° C. for 2 minutes, cooled, concentrated under reduced pressure and chromatographed on silica gel eluting with a gradient of 2, 3.5, 5 and 10% (9:1 MeOH: saturated aqueous NH4OH) in CH2Cl2 to provide the title compound. 1H NMR (CDCl3) δ 2.72 (t, J=5.93 Hz, 2H), 2.91-3.09 (m, 4H), 3.26-3.46 (m, 4H), 4.54 (t, J=5.93 Hz, 2H), 4.79 (s, 2H), 7.09 (dd, J=7.97, 1.19 Hz, 1H), 7.17-7.26 (m, 1H), 7.34-7.41 (m, 1H), 7.89 (dd, J=7.63, 1.86 Hz, 1H); MS (M+H)+ m/z 298.

Provenance & Evidence