Trifluoroacetic acid → 4-Octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl-6,7-dihydro-5h-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine

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Reaction Steps

A solution of Example 59D in CH2Cl2 (2 mL) was treated with trifluoroacetic acid (0.5 mL), stirred for 2 hours, concentrated and partitioned between 1M NaOH solution and CH2Cl2. The organic layer was isolated, dried over MgSO4 and concentrated to yield the title product. 1H NMR (CDCl3) δ 0.86 (m, 1H), 1.77 (m, 5H), 2.16 (m, 2H), 2.30 (m, 1H), 2.64 (m, 3H), 3.03 (m, 1H), 3.43 (m, 3H), 3.87 (m, 2H), 4.73 (bs, 2H), 7.19 (m, 1H), 7.33, (m, 2H), 7.75 (m, 1H). MS (M+H)+ m/z 336.

Provenance & Evidence