Ethanol → HCID 66741343, compound

Participants

Reaction Steps

The product from Example 82A was treated with EtOH (1.5 mL) and 20% Pd(OH)2/C (15 mg), then stirred at ambient temperature under an H2 atmosphere for 16 hours, then diluted with 5:1 CH2Cl2:EtOH, filtered, concentrated and purified by chromatography (eluting with 2, 3.5, 5 and 10% (9:1 MeOH:saturated aqueous NH4OH) in CH2Cl2) to provide the title compound. 1H NMR (CDCl3) δ 1.65-1.86 (m, 2H), 2.01 (d, J=11.53 Hz, 2H), 2.20-2.27 (m, 3H), 2.40-2.49 (m, 1H), 2.62-2.69 (m, 2H), 3.20 (dd, J=11.53, 4.75 Hz, 1H), 3.32 (d, J=12.21 Hz, 1H), 3.46-3.58 (m, 2H), 3.76-3.81 (m, 1H), 4.50 (t, J=4.41 Hz, 1H), 4.71 (s, 2H), 7.20-7.24 (m, 1H), 7.31-7.39 (m, 2H), 7.71-7.75 (m, 1H); MS (M+H)+ m/z 322.

Provenance & Evidence