HCID 86621901, compound → HCID 69225384, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 102A (24.7 mg, 0.044 mmol) was treated with copper(I) cyanide (27.5 mg, 0.307 mmol) in DMF (0.5 mL) heated at 110° C. overnight, cooled, diluted with Et2O (25 mL), washed with water (2×20 mL), washed with brine, dried (MgSO4), filtered, concentrated and purified by chromatography on silica gel eluting with hexane:EtOAc (2:1, 1:1, 4:1) to provide the title compound. MS (M+H)+ m/z 463.

Provenance & Evidence