1-Boc-octahydropyrrolo(3,4-b)pyridine → 4-(3-(R)-Methylamino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidine

Participants

Reaction Steps

The title compound was prepared using the procedure outlined in Example 59D substituting Example 1E for t-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate, and substituting the product from Example 118C for the product from Example 59C, followed by the procedure outlined in Example 59E. 1H NMR (CD3OD) δ 1.84-1.98 (m, 1H), 2.17-2.27 (m, 1H), 2.28-2.36 (m, 2H), 2.41-2.50 (m, 5H), 2.66 (t, 2H), 3.33-3.40 (m, 1H), 3.52-3.61 (m, 1H), 3.72-3.80 (m, 1H), 3.83-3.93 (m, 2H), 7.27-7.33 (m, 1H), 7.37-7.43 (m, 2H), 7.65-7.71 (m, 1H), 8.40-8.44 (m, 1H). MS (M+H)+ m/z 295.

Provenance & Evidence