1-Boc-octahydropyrrolo(3,4-b)pyridine → [1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-4-yl)-azetidin-3-yl]-amine

Participants

Reaction Steps

The title compound was prepared using the procedure outlined in Example 59D substituting Example 2B for t-butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate, and substituting the product from Example 118C for the product from Example 59C, followed by the procedure outlined in Example 59E. 1H NMR (CD3OD) δ 2.20-2.36 (m, 4H), 2.36-2.40 (m, 3H), 2.60 (t, 2H), 3.65-3.74 (m, 1H), 4.06 (dd, 2H), 4.47-4.55 (m, 2H), 7.26-7.34 (m, 1H), 7.36-7.43 (m, 2H), 7.62-7.67 (m, 1H), 8.41-8.44 (m, 1H). MS (M+H)+ m/z 281.

Provenance & Evidence