3-Chloro-2-fluoroaniline → HCID 58318650, compound

Participants

Reaction Steps

1-tert-butyl 2-methyl (2R,4S)-4-[(4-chloro-7-methoxyquinazolin-6-yl)oxy]piperidine-1,2-dicarboxylate (17) was reacted with 3-Chloro-2-fluoroaniline analogously as for the equivalent step in Example 7 to give methyl (2R,4S)-4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidine-2-carboxylate (18): 1H NMR Spectrum: (DMSO-d6) δ1.45-1.56 (2H, m), 2.03-2.12 (1H, m), 2.31-2.38 (1H, m), 2.60-2.67 (1H, m), 3.08-3.15 (1H, m), 3.44-3.48 (1H, m), 3.64 (3H, s), 3.95 (3H, s), 4.55-4.63 (1H, m), 7.23 (1H, s), 7.26-7.32 (1H, m), 7.48-7.58 (2H, m), 7.85 (1H, s), 8.38 (1H, s), 9.56 (1H, s); Mass Spectrum: (M+H)+ 461.

Provenance & Evidence