344240-78-4 → HCID 59000883, compound

HRID 1027949Notes

Reaction equation

HRID 1027949 reaction equation
[F:1][C:2]1[CH:47]=[CH:46][CH:45]=[C:44]([F:48])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:31]([NH:33][O:34][CH3:35])=[O:32])=[CH:26][CH:25]=3)=[C:13]([CH2:14][N:15]([CH3:23])[CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:9]=2[C:8](=[O:36])[N:7]([CH2:37][CH2:38][C:39](OC)=O)[C:6]1=[O:43].NC(CC)[CH2:51][CH2:52][CH2:53][OH:54]>>[F:1][C:2]1[CH:47]=[CH:46][CH:45]=[C:44]([F:48])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:24]3[CH:25]=[CH:26][C:27]([NH:30][C:31]([NH:33][O:34][CH3:35])=[O:32])=[CH:28][CH:29]=3)=[C:13]([CH2:14][N:15]([CH3:23])[CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:9]=2[C:8](=[O:36])[N:7]([CH:37]2[CH2:38][CH2:39][CH:53]([OH:54])[CH2:52][CH2:51]2)[C:6]1=[O:43]

Participants

3

Reactant 2

HCID 547166344240-78-4HCID 59000836HCID 59000836, compound

Product 1

HCID 59000883HCID 59000883, compoundYield 45%

Procedure

The similar reaction as described in Example 5 by using the compound obtained in Example 28 (320 mg, 0.5 mmol) and 4-aminohexanol (86 mg, 0.75 mmol) gave the title compound (154 mg, 45%) as colorless crystals.

Workup

  1. customThe similar reaction

Sources & evidence

ORD record
ord-4e6d6facf8f04ac7a4f947d6f91c625f
Source dataset
uspto-grants-2014_05
Patent number
US08735401B2

Reaction notes

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