Thiophenol → HCID 178516460, compound

Participants

Reaction Steps

A solution of N-(4-acetyl-6-chloropyridin-3-yl)-4-nitrobenzenesulfonamide (1.0 equiv.), dimethylformamidedimethylacetal (4.8 equiv.) and DIEA (4.8 equiv.) in DMF (0.15 M) was heated under Ar at 110° C. for 96 hours. Upon cooling, thiophenol (4.9 equiv.) was added and the solution was stirred at rt for 15 hours. The volatiles were removed in vacuo and following silica gel purification (0-1.5-3-5% MeOH/CH2Cl2) 6-chloro-1,7-naphthyridin-4-ol was obtained (55%). LC/MS=180.9/182.9 (M+H), LC=1.41 min

Provenance & Evidence