反应详情

To a solution of 2-(6-(4-(benzyloxy)quinolin-6-yl)pyridin-2-yl)thiazole (1.0 equiv.) in 1:1 EtOH/EtOAc, at a concentration of 0.1 M, was added 10% palladium on carbon (0.1 eq.). The resultant heterogeneous solution was put under an atmosphere of hydrogen and was stirred for 72 hours. At this time the mixture was filtered through a pad of celite eluting with EtOAc. The volatiles were removed in vacuo yielding 6-(6-(thiazol-2-yl)pyridin-2-yl)quinolin-4-ol (88%). LCMS (m/z): 305.9 (MH+); LC Rt=2.57 min.

1. filtrationAt this time the mixture was filtered through a pad of celite
2. washeluting with EtOAc
3. customThe volatiles were removed in vacuo